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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ANKLE2 All Species: 9.7
Human Site: Y445 Identified Species: 23.7
UniProt: Q86XL3 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.22
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q86XL3 NP_055929.1 938 104114 Y445 V K N S R N K Y D K T P E D V
Chimpanzee Pan troglodytes XP_001152324 477 52209 L19 A A L A W E L L G A S V L L I
Rhesus Macaque Macaca mulatta XP_001087028 488 53959 L30 G H Y Y V P L L R A E D T S S
Dog Lupus familis XP_852228 959 106035 Y450 V K N P R N K Y D K T P E D V
Cat Felis silvestris
Mouse Mus musculus Q6P1H6 964 106180 K452 I V K N R K N K Y G K T P E E
Rat Rattus norvegicus Q7TP65 931 103345 K453 I V K N P R N K Y G K T P E D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510952 1025 112758 Y449 V K N P K N K Y E K T P E D V
Chicken Gallus gallus XP_415084 889 99899 T419 P R N K Y D Q T P A E V I C E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001119867 961 106362 A458 G P L S P S K A D E F R R A W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_001023515 580 64455 F122 L V D S N P R F L V N T G G D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 49.1 49.1 73.9 N.A. 68.4 67.8 N.A. 58.2 54.6 N.A. 49.6 N.A. N.A. N.A. 23 N.A.
Protein Similarity: 100 49.6 50.4 82.4 N.A. 77.6 76.2 N.A. 69.7 66.8 N.A. 65.7 N.A. N.A. N.A. 34.8 N.A.
P-Site Identity: 100 0 0 93.3 N.A. 6.6 0 N.A. 80 6.6 N.A. 20 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 20 0 93.3 N.A. 26.6 20 N.A. 93.3 26.6 N.A. 33.3 N.A. N.A. N.A. 33.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 0 10 0 0 0 10 0 30 0 0 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % C
% Asp: 0 0 10 0 0 10 0 0 30 0 0 10 0 30 20 % D
% Glu: 0 0 0 0 0 10 0 0 10 10 20 0 30 20 20 % E
% Phe: 0 0 0 0 0 0 0 10 0 0 10 0 0 0 0 % F
% Gly: 20 0 0 0 0 0 0 0 10 20 0 0 10 10 0 % G
% His: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 20 0 0 0 0 0 0 0 0 0 0 0 10 0 10 % I
% Lys: 0 30 20 10 10 10 40 20 0 30 20 0 0 0 0 % K
% Leu: 10 0 20 0 0 0 20 20 10 0 0 0 10 10 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 40 20 10 30 20 0 0 0 10 0 0 0 0 % N
% Pro: 10 10 0 20 20 20 0 0 10 0 0 30 20 0 0 % P
% Gln: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % Q
% Arg: 0 10 0 0 30 10 10 0 10 0 0 10 10 0 0 % R
% Ser: 0 0 0 30 0 10 0 0 0 0 10 0 0 10 10 % S
% Thr: 0 0 0 0 0 0 0 10 0 0 30 30 10 0 0 % T
% Val: 30 30 0 0 10 0 0 0 0 10 0 20 0 0 30 % V
% Trp: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 10 % W
% Tyr: 0 0 10 10 10 0 0 30 20 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _